期刊
CIRCULATION-CARDIOVASCULAR IMAGING
卷 5, 期 3, 页码 349-356出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCIMAGING.111.969956
关键词
normal-weight obesity; left ventricular function; echocardiography
资金
- Wroclaw Medical University
Background-Obesity predisposes to left ventricular (LV) dysfunction and heart failure; however, the risk of these complications has not been assessed in patients with a normal body mass index (BMI) but increased body fat content (normal-weight obesity, NWO). We hypothesized that LV performance in NWO may be impaired and sought to investigate potential contributors to cardiac functional abnormalities. Methods and Results-One hundred sixty-eight subjects (age, 38 +/- 7 years) with BMI <25kg/m(2) and no history of any disease affecting the myocardium were classified on the basis of body fat content into 2 groups: with NWO and without NWO. Echocardiographic indices of LV systolic and diastolic function, including myocardial velocities and deformation, serological fibrosis markers, indicators of proinflammatory activation, and metabolic control, were evaluated. Subjects with NWO demonstrated impaired LV systolic and diastolic function, increased fibrosis intensity (assessed by procollagen type I carboxy-terminal propeptide [PICP]), impaired insulin sensitivity, and increased proinflammatory activation as compared with individuals with normal body fat. The independent correlates of LV systolic and diastolic function variables were as follows: for strain, IL-18 (beta = -0.17, P < 0.006), C-reactive protein (beta = -0.20, P < 0.002) and abdominal fat deposit (beta = -0.20, P < 0.003); for tissue S velocity, PICP (beta = -0.21, P < 0.002) and abdominal fat deposit (beta = -0.43, P < 0.0001); for tissue E velocity, abdominal fat deposit (beta = -0.30, P < 0.0001), PICP (beta = -0.31, P < 0.0001) and homeostasis model assessment of insulin resistance index (HOMA IR; beta = -0.20, P < 0.002); and for E/e'-PICP, IL-18 (both beta = 0.18, P < 0.01) and HOMA IR (beta = 0.16, P < 0.04). Conclusions-In patients with NWO, subclinical disturbances of LV function are independently associated with the extent of abdominal fat deposit, profibrotic state (as reflected by circulating PICP), reduced insulin sensitivity, and proinflammatory activation. (Circ Cardiovasc Imaging. 2012;5:349-356.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据