期刊
CIRCULATION-CARDIOVASCULAR GENETICS
卷 7, 期 6, 页码 941-954出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCGENETICS.114.000550
关键词
biomarkers; cardiovascular diseases; lipids; mass spectrometry
资金
- King's British Heart Foundation Centre
- Heart Research UK
- Department of Health via the National Institute for Health Research Biomedical Research Centre based at Guy's and St. Thomas' National Health Service Foundation Trust
- King's College London
- British Heart Foundation [FS/13/2/29892] Funding Source: researchfish
Lipidomics is the comprehensive analysis of molecular lipid species, including their quantitation and metabolic pathways. The huge diversity of native lipids and their modifications make lipidomic analyses challenging. The method of choice for sensitive detection and quantitation of molecular lipid species is mass spectrometry, either by direct infusion (shotgun lipidomics) or coupled with liquid chromatography. Although shotgun lipidomics allows for high-throughput analysis, low-abundant lipid species are not detected. Previous separation of lipid species by liquid chromatography increases ionization efficiency and is better suited for quantifying low abundant and isomeric lipid species. In this review, we will discuss the potential of lipidomics for cardiovascular research. To date, cardiovascular research predominantly focuses on the role of lipid classes rather than molecular entities. An in-depth knowledge about the molecular lipid species that contribute to the pathophysiology of cardiovascular diseases may provide better biomarkers and novel therapeutic targets for cardiovascular disease.
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