期刊
CIRCULATION-CARDIOVASCULAR GENETICS
卷 2, 期 4, 页码 322-U48出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCGENETICS.108.833806
关键词
genetics; heart rate; population
资金
- European Commission [018947 (LSHG-CT-2006-01947)]
- Croatian Ministry of Science, Education and Sport [108-1080315-0302]
- Ministry of Health of the Autonomous Province of Bolzano
- South Tyrolean Sparkasse Foundation
- Scottish Executive Health Department
- Royal Society
- Wellcome Trust
- Netherlands Organization for Scientific Research (NWO) [91203014]
- Russian Foundation for Basic Research (NWO-RFBR) [047.017.043]
- Center of Medical Systems Biology (CMSB)
- Netherlands Genomics Initiative
- Chief Scientist Office [CZB/4/710] Funding Source: researchfish
- Medical Research Council [MC_U127561128] Funding Source: researchfish
- MRC [MC_U127561128] Funding Source: UKRI
Background-We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. Methods and Results-We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P = 3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P = 2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P = 4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. Conclusion-Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP. (Circ Cardiovasc Genet. 2009; 2: 322-328.)
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