期刊
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
卷 6, 期 1, 页码 84-90出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCEP.112.975342
关键词
atrial fibrillation; ECG; epidemiology; heart failure; risk factors
资金
- Intramural Research Program of the National Institutes of Health, National Institute on Aging
- American Heart Association Award [09FTF2190028]
- National Institute on Aging (NIA) [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106]
- NIA grant [R01-AG028050]
- National Institute of Nursing Research grant [R01-NR012459]
- National Institutes of Health [1RC1HL101056, 1RO1HL092577, 5R21DA027021, 1RO1HL104156, 1K24HL105780, K23DK089118]
Background- The electrocardiographic PR interval increases with aging, differs by race, and is associated with atrial fibrillation (AF), pacemaker implantation, and all-cause mortality. We sought to determine the associations between PR interval and heart failure, AF, and mortality in a biracial cohort of older adults. Methods and Results- The Health, Aging, and Body Composition (Health ABC) Study is a prospective, biracial cohort. We used multivariable Cox proportional hazards models to examine PR interval (hazard ratios expressed per SD increase) and 10-year risks of heart failure, AF, and all-cause mortality. Multivariable models included demographic, anthropometric, and clinical variables in addition to established cardiovascular risk factors. We examined 2722 Health ABC participants (aged 74 +/- 3 years, 51.9% women, and 41% black). We did not identify significant effect modification by race for the outcomes studied. After multivariable adjustment, every SD increase (29 ms) in PR interval was associated with a 13% greater 10-year risk of heart failure (95% confidence interval, 1.02-1.25) and a 13% increased risk of incident AF (95% confidence interval, 1.04-1.23). PR interval >200 ms was associated with a 46% increased risk of incident heart failure (95% confidence interval, 1.11-1.93). PR interval was not associated with increased all-cause mortality. Conclusions- We identified significant relationships of PR interval to heart failure and AF in older adults. Our findings extend prior investigations by examining PR interval and associations with adverse outcomes in a biracial cohort of older men and women.
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