期刊
CIRCULATION RESEARCH
卷 123, 期 7, 页码 803-824出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.312208
关键词
autophagy; caloric restriction; cardiovascular diseases; heart; longevity
资金
- Austrian Science Fund FWF [P27637-B28, 3301-B31]
- European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR)
- Ligue contre le Cancer Comite de Charente-Maritime (equipe labelisee)
- Agence National de la Recherche (ANR)
- ANR
- ERA-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ile-de-France
- Chancelerie des universites de Paris (Legs Poix)
- Fondation pour la Recherche Medicale (FRM)
- European Commission (ArtForce)
- European Research Council (ERC)
- Fondation Carrefour
- Institut National du Cancer (INCa)
- Inserm (HTE)
- Institut Universitaire de France
- LeDucq Foundation
- LabEx Immuno-Oncology
- RHU Torino Lumiere
- Seerave Foundation
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes
- Austrian Science Fund FWF (Austria) [P23490-B20, P29262, P24381, P29203, P27893, I1000]
- SFB Lipotox [F3012]
- BMWFW
- Karl-Franzens University
- NAWI Graz
- BioTechMed-Graz flagship project EPIAge
- grant DKplus Metabolic and Cardiovascular Diseases [W1226]
- Austrian Science Fund (FWF) [P27637, P29203] Funding Source: Austrian Science Fund (FWF)
Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life - and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.
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