4.7 Article

Autophagy in Cardiovascular Aging

期刊

CIRCULATION RESEARCH
卷 123, 期 7, 页码 803-824

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.312208

关键词

autophagy; caloric restriction; cardiovascular diseases; heart; longevity

资金

  1. Austrian Science Fund FWF [P27637-B28, 3301-B31]
  2. European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR)
  3. Ligue contre le Cancer Comite de Charente-Maritime (equipe labelisee)
  4. Agence National de la Recherche (ANR)
  5. ANR
  6. ERA-Net for Research on Rare Diseases
  7. Association pour la recherche sur le cancer (ARC)
  8. Canceropole Ile-de-France
  9. Chancelerie des universites de Paris (Legs Poix)
  10. Fondation pour la Recherche Medicale (FRM)
  11. European Commission (ArtForce)
  12. European Research Council (ERC)
  13. Fondation Carrefour
  14. Institut National du Cancer (INCa)
  15. Inserm (HTE)
  16. Institut Universitaire de France
  17. LeDucq Foundation
  18. LabEx Immuno-Oncology
  19. RHU Torino Lumiere
  20. Seerave Foundation
  21. SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
  22. SIRIC Cancer Research and Personalized Medicine (CARPEM)
  23. Paris Alliance of Cancer Research Institutes
  24. Austrian Science Fund FWF (Austria) [P23490-B20, P29262, P24381, P29203, P27893, I1000]
  25. SFB Lipotox [F3012]
  26. BMWFW
  27. Karl-Franzens University
  28. NAWI Graz
  29. BioTechMed-Graz flagship project EPIAge
  30. grant DKplus Metabolic and Cardiovascular Diseases [W1226]
  31. Austrian Science Fund (FWF) [P27637, P29203] Funding Source: Austrian Science Fund (FWF)

向作者/读者索取更多资源

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life - and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.

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