期刊
CIRCULATION RESEARCH
卷 109, 期 1, 页码 97-109出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.110.224600
关键词
genetic testing; ion channels; sudden death; ventricular fibrillation; atrial fibrillation
资金
- Ministry of Health, Labour, and Welfare, Japan [21C-8, 22-4-7]
- Ministry of Education, Culture, and Technology of Japan
- Uehara Memorial Foundation
- [H18]
- [002]
- Grants-in-Aid for Scientific Research [23390209] Funding Source: KAKEN
Since 1995, when a potassium channel gene, hERG (human either-a-go-go-related gene), now referred to as KCNH2, encoding the rapid component of cardiac delayed rectifier potassium channels was identified as being responsible for type 2 congenital long-QT syndrome, a number of potassium channel genes have been shown to cause different long-QT syndrome, short-QT syndrome, Brugada syndrome, early repolarization syndrome, and familial atrial fibrillation. Genotype-phenotype correlations have been investigated in some inherited arrhythmia syndromes, and as a result, gene-specific risk stratification and gene-specific therapy and management structure and function of potassium channels, the clinical phenotype due to potassium channel gene mutations, including genotype-phenotype correlations and the diverse mechanisms unverlying the potassium channel gene-related diseases will be discussed. (Circ Res. 2011;109:97-109.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据