期刊
CIRCULATION RESEARCH
卷 106, 期 10, 页码 1559-1569出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.110.216523
关键词
inflammation; insulin resistance; atherosclerosis; diabetes; PPARs; alternatively activated macrophages
资金
- NIH [DK062386, HL076746, DK081405]
- American Diabetes Association
- Larry L. Hillblom Foundation Network
Macrophages, a key component of the innate defense against pathogens, participate in the initiation and resolution of inflammation, and in the maintenance of tissues. These diverse and at times antithetical functions of macrophages are executed via distinct activation states, ranging from classical to alternative to deactivation. Because the dysregulation of macrophage activation is pathogenically linked to various metabolic, inflammatory and immune disorders, regulatory proteins controlling macrophage activation have emerged as important new therapeutic targets. Here, the mechanisms by which peroxisome proliferator-activated receptors (PPARs) transcriptionally regulate macrophage activation in health and disease states, including obesity, insulin resistance and cardiovascular disease, are reviewed. (Circ Res. 2010;106:1559-1569.)
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