期刊
CIRCULATION RESEARCH
卷 107, 期 11, 页码 1304-1312出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.110.231910
关键词
fibroblasts; fibrosis; fate mapping
资金
- American Heart Association [SDG0735602T]
- NIH [1K08 CA129204, DK 061688, AA 013913, DK 55001, CA 125550, CA 151925]
- Division of Matrix Biology at the Beth Israel Deaconess Medical Center
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that cardiac fibroblasts are a heterogeneous population and likely derive from various distinct tissue niches in health and disease. Here, we review our emerging understanding of where cardiac fibroblasts come from, as well as how we can possibly use this knowledge to develop novel therapies for cardiac fibrosis. (Circ Res. 2010;107:1304-1312.)
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