期刊
CIRCULATION RESEARCH
卷 104, 期 3, 页码 292-303出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.108.189050
关键词
sodium; ischemia/reperfusion; heart failure; calcium; mitochondria; ion transport
资金
- British Heart Foundation Funding Source: Medline
- Intramural NIH HHS [Z99 HL999999] Funding Source: Medline
The transmembrane sodium gradient is essential for both excitability of the cardiac cell and the regulation of the cytoplasmic concentrations of Ca and protons. In addition, movements of Na across the mitochondrial membrane affect matrix protons and calcium. In the first part of the review, we discuss the most important pathways responsible for sarcolemmal and mitochondrial sodium movements. The bulk of the review considers the changes of intracellular Na concentration ([ Na+] (i)) that occur in disease, specifically, ischemia, reperfusion, and heart failure. We review evidence implicating the increase of intracellular sodium to either increased influx of sodium ( via either sodium channels or sodium/hydrogen exchange) or, alternatively, to decreased efflux on the Na/K pump. Although much has been learned about sodium regulation in the heart, there are still many unanswered questions, particularly concerning mitochondrial Na regulation. ( Circ Res. 2009; 104: 292-303.)
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