期刊
CIRCULATION RESEARCH
卷 104, 期 4, 页码 428-441出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.108.188144
关键词
angiogenesis; axon guidance; VEGF; semaphorin; netrin
资金
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Agence Nationale de la Recherche (ANR) (Programme Cardiovasculaire Obesite Diabete [PCOD]. Neuroscience, Programme Blanc)
- Association pour la Recherche sur le Cancer-Institut National du Cancer (ARC-INCa)
- Institut de France (Cino del Duca)
- and the European Community [LSHG-CT-2004-503573]
- Association pour la Recherche sur le Cancer (ARC)
- Fundacao para a Ciencia e a Tecnologia, Portugal
- INSERM
The vascular system of vertebrates consists of an organized, branched network of arteries, veins, and capillaries that penetrates all the tissues of the body. One of the most striking features of the vascular system is that its branching pattern is highly stereotyped, with major and secondary branches forming at specific sites and developing highly conserved organ-specific vascular patterns. The factors controlling vascular patterning are not yet completely understood. Recent studies have highlighted the anatomic and structural similarities between blood vessels and nerves. The 2 networks are often aligned, with nerve fibers and blood vessels following parallel routes. Furthermore, both systems require precise control over their guidance and growth. Several molecules with attractive and repulsive properties have been found to modulate the proper guidance of both nerves and blood vessels. These include the Semaphorins, the Slits, and the Netrins and their receptors. In this review, we describe the molecular mechanisms by which blood vessels and axons achieve proper path finding and the molecular cues that are involved in their guidance. (Circ Res. 2009;104:428-441.)
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