期刊
CIRCULATION RESEARCH
卷 102, 期 5, 页码 519-528出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.107.168369
关键词
aging; antioxidants; caloric restriction; nuclear receptors; redox
资金
- Intramural NIH HHS [Z01 AG000368-03] Funding Source: Medline
- NHLBI NIH HHS [R01 HL077256, HL077256, HL43023, P01 HL043023] Funding Source: Medline
This review focuses on the emerging evidence that attenuation of the production of reactive oxygen species and inhibition of inflammatory pathways play a central role in the antiaging cardiovascular effects of caloric restriction. Particular emphasis is placed on the potential role of the plasma membrane redox system in caloric restriction-induced pathways responsible for sensing oxidative stress and increasing cellular oxidative stress resistance. We propose that caloric restriction increases bioavailability of NO, decreases vascular reactive oxygen species generation, activates the Nrf2/antioxidant response element pathway, inducing reactive oxygen species detoxification systems, exerts antiinflammatory effects, and, thereby, suppresses initiation/progression of vascular disease that accompany aging.
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