期刊
CIRCULATION RESEARCH
卷 103, 期 5, 页码 450-453出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.108.179861
关键词
-
资金
- Agence Nationale de la Recherche and Genfit SA (COMAX)
- Region Nord-Pas de Calais/FEDER
- Fondation Coeur et Arteres
- European Vascular Genomics Network
Hypertriglyceridemia is an independent risk factor for coronary artery disease. Because apolipoprotein (Apo) A5 regulates plasma triglyceride levels, we investigated the impact of human (h)ApoA5 on atherogenesis. The influence of hApoA5 transgenic expression was studied in the ApoE2 knock-in mouse model of mixed dyslipidemia. Our results demonstrate that hApoA5 lowers plasma triglyceride levels in Western diet-fed ApoE2 knock-in mice. Moreover, atherosclerotic lesion development was significantly decreased in the hApoA5 transgenic mice. Finally, pharmacologic activation of hApoA5 expression by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate resulted in an enhanced atheroprotection. These results identify an atheroprotective role of hApoA5 in a mouse model of mixed dyslipidemia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据