期刊
CIRCULATION JOURNAL
卷 76, 期 5, 页码 1145-1150出版社
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-11-0929
关键词
Doppler tissue imaging change; Heart failure
资金
- National Science Council of the Republic of China, Taiwan [NMRPG360341]
- Chang Gung Memorial Hospital [CMRPG371951]
Background: Early (e')/late (a') diastolic mitral annular velocity ratio is a powerful independent predictor of poor prognosis in patients with left ventricular (LV) dysfunction. Doppler tissue imaging, however, may change over time according to intervention and medical treatment. The aim of the present study was to prospectively evaluate whether, in clinically stable patients with chronic heart failure (CHF), the decrease of an initially high e'/a' ratio on long-term therapy predicts a more favorable outcome. Methods and Results: One hundred and eighty-one adult patients with CHF and high e'/a' ratio (>= 0.74) underwent repeat echocardiography 6 months after the initial examination, and were then followed up for a mean period of 20 months. After 6 months, e'/a' ratio did not change in 95 patients, whereas it was significantly decreased (<0.74) in the remaining 86 patients. During follow-up, 55 participants (30%) had cardiac events. According to multivariate Cox regression analysis, decrease in e'/a' ratio, initial New York Heart Association class III or IV, and change in LV mass index as well as in systolic mitral annular velocities emerged as independent predictors of survival. Conclusions: The decrease of an initially high e'/a' ratio on long-term therapy predicts a more favorable outcome in clinically stable patients with CHF. (Circ J 2012; 76: 1145-1150)
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