期刊
CIRCULATION JOURNAL
卷 72, 期 1, 页码 1-16出版社
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.72.1
关键词
reactive oxygen species; selenocysteine; selenoproteins; thiol
资金
- NHLBI NIH HHS [HL61795, HV28718, HL81857, HL58976] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL061795, R37HL061795, R01HL081857, R01HL058976] Funding Source: NIH RePORTER
The oxidizing nature of the extracellular environment is vastly different from the highly reducing nature of the intracellular compartment. The redox potential of the cytosolic compartment of the intracellular environment limits disulfide bond formation, whereas the oxidizing extracellular environment contains proteins rich in disulfide bonds. If not for an extracellular antioxidant system to eliminate reactive oxygen and nitrogen species, lipid peroxidation and protein oxidation would become excessive, resulting in cellular damage. Many reviews have focused on the role of intracellular antioxidants in the elimination of oxidative stress, but this one will focus on the coordinated action of both intracellular and extracellular antioxidants in limiting cellular oxidant stress.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据