期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 36, 页码 10545-10549出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201504524
关键词
alkenes; cross-coupling; enols; Grignard reaction; iron catalysis
资金
- Deutsche Forschungsgemeinschaft (DFG)
Stable CO linkages are generally unreactive in cross-coupling reactions which mostly employ more electrophilic halides or activated esters (triflates, tosylates). Acetates are cheap and easily accessible electrophiles but have not been used in cross-couplings because the strong CO bond and high propensity to engage in unwanted acetylation and deprotonation. Reported herein is a selective iron-catalyzed cross-coupling of diverse alkenyl acetates, and it operates under mild reaction conditions (0 degrees C, 2h) with a ligand-free catalyst (1-2mol%).
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