4.8 Article

Natural History of Very Severe Aortic Stenosis

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CIRCULATION
卷 121, 期 1, 页码 151-156

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.109.894170

关键词

aortic stenosis; risk factors; stenosis; valves

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Background-We sought to assess the outcome of asymptomatic patients with very severe aortic stenosis. Methods and Results-We prospectively followed 116 consecutive asymptomatic patients (57 women; age, 67+/-16 years) with very severe isolated aortic stenosis defined by a peak aortic jet velocity (AV-Vel) >= 5.0 m/s (average AV-Vel, 5.37+/-0.35 m/s; valve area, 0.63+/-0.12 cm(2)). During a median follow-up of 41 months (interquartile range, 26 to 63 months), 96 events occurred (indication for aortic valve replacement, 90; cardiac deaths, 6). Event-free survival was 64%, 36%, 25%, 12%, and 3% at 1, 2, 3, 4, and 6 years, respectively. AV-Vel but not aortic valve area was shown to independently affect event-free survival. Patients with an AV-Vel >= 5.5 m/s had an event-free survival of 44%, 25%, 11%, and 4% at 1, 2, 3, and 4 years, respectively, compared with 76%, 43%, 33%, and 17% for patients with an AV-Vel between 5.0 and 5.5 m/s (P<0.0001). Six cardiac deaths occurred in previously asymptomatic patients (sudden death, 1; congestive heart failure, 4; myocardial infarction, 1). Patients with an initial AV-Vel >= 5.5 m/s had a higher likelihood (52%) of severe symptom onset (New York Heart Association or Canadian Cardiovascular Society class >II) than those with an AV-Vel between 5.0 and 5.5 m/s (27%; P=0.03). Conclusions-Despite being asymptomatic, patients with very severe aortic stenosis have a poor prognosis with a high event rate and a risk of rapid functional deterioration. Early elective valve replacement surgery should therefore be considered in these patients. (Circulation. 2010; 121: 151-156.)

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