期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 148, 期 -, 页码 27-34出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2015.01.017
关键词
Siderophore; Iron uptake; Siderosome; Nonribosomal peptide synthetase; Pseudomonas aeruginosa
资金
- Centre National de la Recherche Scientifique
- icFRC
- ANR (Agence Nationale de Recherche) [IronPath ANR-12-BSV8-0007-01]
- Innovative Medicines Joint Undertaking [115525]
- European Union
- French Ministere de la Recherche et de la Technologie
Pyoverdine I (PVDI) and pyochelin (PCH) are the two major siderophores produced by Pseudomonas aeruginosa PAO1 to import iron. The biochemistry of the biosynthesis of these two siderophores has been described in detail in the literature over recent years. PVDI assembly requires the coordinated action of seven cytoplasmic enzymes and is followed by a periplasmic maturation before secretion of the siderophore into the extracellular medium by the efflux system PvdRT-OpmQ PCH biosynthesis also involves seven cytoplasmic enzymes but no periplasmic maturation. Recent findings indicate that the cytoplasmic enzymes involved in each of these two siderophore biosynthesis pathways can form siderophore-specific multi-enzymatic complexes called siderosomes associated with the inner leaflet of the cytoplasmic membrane. This organization may optimize the transfer of the siderophore precursors between the various participating enzymes and avoid the diffusion of siderophore precursors, able to chelate metals, throughout the cytoplasm. Here, we describe these recently published findings and discuss the existence of these siderosomes in P. aeruginosa. (C) 2015 Elsevier Inc. All rights reserved.
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