期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 153, 期 -, 页码 32-41出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2015.08.016
关键词
Corroles; trans-A(2)B corroles; Platinum(II) complexes; Human serum albumin (HSA); Deoxyribonucleic acid (DNA); Plasmid DNA (pDNA)
资金
- FCT/MEC [FCT UID/QUI/00062/2013]
- IBILI research Unit [FCT UID/NEU104539/2013]
- CICECO-Aveiro Institute of Materials through national funds [FCT UID/CTM/50011/2013]
- FEDER [PT2020]
- Portuguese NMR Network
- CNPq (Brazil) [200802/2012-7, 443625/2014-0]
- BJT grant [405588/2013-5]
- FCT [SFRH/BPD/63237/2009, SFRH/BD/85941/2012]
A simple methodology giving access to the metal-free corroles of trans-A(2)B type, 5,15-bis (pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-(4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure. (C) 2015 Elsevier Inc. All rights reserved.
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