期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 2, 页码 593-597出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201508710
关键词
antibiotics; drug delivery; nanotubes; surface plasmon resonance
资金
- National Natural Science Foundation of China [21322504, 11174046, 21275026]
- Fundamental Research Funds for the Central Universities [N140505001, N140504006]
- Alexander von Humboldt Foundation
- ERC
- DFG
- DFG funCOS
- DFG cluster of excellence
In this work, we use a double-layered stack of TiO2 nanotubes (TiNTs) to construct a visible-light-triggered drug delivery system. The key for visible light drug release is a hydrophobic cap on the nanotubes containing Au nanoparticles (AuNPs). The AuNPs allow for a photocatalytic scission of the hydrophobic chain under visible light. To demonstrate this principle, we loaded ampicillin (AMP) into the lower part of the TiO2 nanotube stack, triggered visible-light-induced release, and carried out antibacterial studies. The release from the platform becomes most controllable if the drug is silane-grafted in the hydrophilic bottom layer for drug storage. Thus, visible light photocatalysis can also determine the release kinetics of the active drug from the nanotube wall.
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