相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors
E. M. Dunbar et al.
INVESTIGATIONAL NEW DRUGS (2014)
A new locus for X-linked dominant CharcotMarieTooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene
Marina L. Kennerson et al.
HUMAN MOLECULAR GENETICS (2013)
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
Joanna Kaplon et al.
NATURE (2013)
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase
Shih-Chia Tso et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Phenylbutyrate Therapy for Pyruvate Dehydrogenase Complex Deficiency and Lactic Acidosis
Rosa Ferriero et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Clinical and Experimental Applications of Sodium Phenylbutyrate
Tommaso Iannitti et al.
Drugs in research & development (2013)
Phenylbutyrate increases activity of pyruvate dehydrogenase complex.
Rosa Ferriero et al.
ONCOTARGET (2013)
Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants
Jerome Kluza et al.
CANCER RESEARCH (2012)
Spectrum of neurological and survival outcomes in pyruvate dehydrogenase complex (PDC) deficiency: Lack of correlation with genotype
Suzanne D. DeBrosse et al.
MOLECULAR GENETICS AND METABOLISM (2012)
Urinary phenylacetylglutamine as dosing biomarker for patients with urea cycle disorders
M. Mokhtarani et al.
MOLECULAR GENETICS AND METABOLISM (2012)
Suggested guidelines for the diagnosis and management of urea cycle disorders
Johannes Haeberle et al.
ORPHANET JOURNAL OF RARE DISEASES (2012)
Phenylbutyrate therapy for maple syrup urine disease
Nicola Brunetti-Pierri et al.
HUMAN MOLECULAR GENETICS (2011)
Metabolic Modulation of Glioblastoma with Dichloroacetate
E. D. Michelakis et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
E. D. Michelakis et al.
BRITISH JOURNAL OF CANCER (2008)
Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity
R. Max Wynn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells
Thomas McFate et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
Chun-Wun Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate
Peter W. Stacpoole et al.
PEDIATRICS (2008)
Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer
T. E. Roche et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children
PW Stacpoole et al.
PEDIATRICS (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Dichloroacetate causes toxic neuropathy in MELAS - A randomized, controlled clinical trial
P Kaufmann et al.
NEUROLOGY (2006)
Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
TR Knoechel et al.
BIOCHEMISTRY (2006)
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
M Kato et al.
EMBO JOURNAL (2005)
Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components
Y Hiromasa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
MC Sugden et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
The protein kinase complement of the human genome
G Manning et al.
SCIENCE (2002)
Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase
LG Korotchkina et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structure of rat BCKD kinase: Nucleotide-induced domain communication in a mitochondrial protein kinase
M Machius et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Probing the mechanism of inactivation of human pyruvate dehydrogenase by phosphorylation of three sites
LG Korotchkina et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
JC Baker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
GHKL, an emergent ATPase/kinase superfamily
R Dutta et al.
TRENDS IN BIOCHEMICAL SCIENCES (2000)
Mechanistic and kinetic studies of inhibition of enzymes
CG Whiteley
CELL BIOCHEMISTRY AND BIOPHYSICS (2000)