期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 34, 页码 10005-10008出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201504926
关键词
alkynes; lactams; medium-ring compounds; ring expansion; triflimide
资金
- Hong Kong RGC [16304714]
- National Natural Science Foundation of China [21490570, 21372023, 21490572]
- Shenzhen Science and Technology Innovation Committee [SW201110018, JSGG20140519105550503]
A mild and efficient intermolecular ring-expansion approach was developed for the synthesis of medium-ring lactams by using siloxy alkynes. Key to success is the suitable combination of a superior catalyst and an exceptional nitrogen-protecting group. Control experiments indicated that the reaction is remarkably selective toward the desired lactam formation, even with many possible non-productive pathways.
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