期刊
JOURNAL OF INFECTIOUS DISEASES
卷 212, 期 9, 页码 1500-1508出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv234
关键词
syndecan-4; acute bacterial pneumonia; S. pneumoniae; survival; biomarker
资金
- Ministry of Health, Labour and Welfare, Japan
- Grants-in-Aid for Scientific Research [15K08359, 25460596, 25293129] Funding Source: KAKEN
Background. Syndecan-4 is a transmembrane heparan sulfate proteoglycan expressed in a variety of cells, and glycosaminoglycan side chains of syndecan-4 bind to several proteins, suggesting several biological functions. However, the role of syndecan-4 in acute bacterial pneumonia has not yet been elucidated. Methods. Serumsyndecan-4 levels were measured in patients with acute pneumonia, and the relationships between serum syndecan-4 levels and clinical parameters were analyzed. Next, we treated wild-type and syndecan-4-deficient mice with Streptococcus pneumoniae intranasally and analyzed the phenotype of syndecan-4-deficient mice. Results. In the patients with acute pneumonia, serumsyndecan-4 levels were significantly higher than in the healthy volunteers and correlated negatively with the pneumonia severity score. In addition, in patients who improved with short-term antibiotic therapy, serum syndecan-4 levels were higher on admission and gradually increased during antibiotic therapy. Furthermore, in syndecan-4-deficient mice, the survival rate was significantly worse, and total neutrophil counts in bronchoalveolar lavage fluid, bacterial counts in blood, and plasma levels of inflammatory cytokines were significantly higher than in wild-type mice. Conclusions. These results suggest that syndecan-4 has an anti-inflammatory function in acute pneumonia and could serve as a useful biomarker in these patients.
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