期刊
JOURNAL OF INFECTIOUS DISEASES
卷 213, 期 9, 页码 1472-1475出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv752
关键词
artemisinin resistance; K13; Plasmodium falciparum; malaria; South America; Guyana; ACT
资金
- Centers for Disease Control and Prevention (CDC) Antimicrobial Resistance Working Group
- Amazon Malaria Initiative
- US Agency for International Development
- American Society of Microbiology/CDC
- Atlanta Research and Education Foundation
- Atlanta VA Medical Center
Suspected artemisinin resistance in Plasmodium falciparum can be explored by examining polymorphisms in the Kelch (PfK13) propeller domain. Sequencing of PfK13 and other gene resistance markers was performed on 98 samples from Guyana. Five of these samples carried the C580Y allele in the PfK13 propeller domain, with flanking microsatellite profiles different from those observed in Southeast Asia. These molecular data demonstrate independent emergence of the C580Y K13 mutant allele in Guyana, where resistance alleles to previously used drugs are fixed. Therefore, in Guyana and neighboring countries, continued molecular surveillance and periodic assessment of the therapeutic efficacy of artemisinin-based combination therapy are warranted.
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