期刊
JOURNAL OF INFECTIOUS DISEASES
卷 212, 期 8, 页码 1270-1278出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv210
关键词
Avian influenza; H7 hemagglutinin; live attenuated; vaccine; antibody affinity; anti-stalk antibodies; memory B cells
资金
- National Institutes of Health (NIH) Respiratory Pathogens Research Center [HHSN272201200005C]
- Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), NIH
- NIH Centers for Excellence in Influenza Research and Surveillance [HHSN272201400008C, HHSN266200700008C]
- DIR, NIAID, NIH [HHSN272200900026C]
Recent studies have shown that live attenuated influenza vaccines (LAIVs) expressing avian influenza virus hemagglutinins (HAs) prime for strong protective antibody responses to an inactivated influenza vaccine (IIV) containing the HA. To better understand this priming effect, we compared H7 HA head and stalk domain-specific B-cell responses in H7N7 LAIV-primed subjects and non-H7-primed controls after a single dose of H7N7 IIV. As previously reported, H7N7 LAIV-primed subjects but not control subjects generated strong hemagglutination-inhibiting and neutralizing antibody responses to the H7N7 IIV. Here, we found that the quantity, epitope diversity, and affinity of H7 head-specific antibodies increased rapidly in only H7N7 LAIV-primed subjects after receipt of the IIV. However, all cohorts generated a vigorous, high-affinity, stalk-specific antibody response. Consistent increases in circulating memory B-cell frequencies after receipt of the IIV reflected the specificity of high-affinity antibody production. Our findings emphasize the value of LAIVs as a vehicle for prepandemic vaccination.
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