期刊
JOURNAL OF INFECTIOUS DISEASES
卷 212, 期 1, 页码 81-85出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv018
关键词
influenza A virus; human; CD8(+) T cells; immunity; longevity
资金
- National Institute of Allergy and Infectious Diseases, National Institutes of Health [HHSN272201400008C]
- European Union [602604]
- European Commission [101920]
Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.
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