期刊
CHRONOBIOLOGY INTERNATIONAL
卷 31, 期 6, 页码 779-786出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07420528.2014.900501
关键词
Actigraphy; circadian rhythm; elderly; light at night; melatonin; nighttime blood pressure
资金
- Department of Indoor Environmental Medicine, Nara Medical University
- Ministry of Education, Culture, Sports, Science and Technology
- Mitsui Sumitomo Insurance Welfare Foundation
- Meiji Yasuda Life Foundation of Health and Welfare
- Osaka Gas Group Welfare Foundation
- Japan Diabetes Foundation
- Japan Science and Technology Agency
Circadian misalignment between internal and environmental rhythms dysregulates blood pressure (BP) variability because of disruption of the biological clock, resulting in increased nighttime BP. Although exposure to light-at-night is associated with the circadian misalignment, it remains unclear whether exposure to light-at-night in home settings is associated with nighttime BP. In this cross-sectional analysis of 528 elderly individuals (mean age: 72.8 years), we measured bedroom light intensity at 1-min intervals on two consecutive nights along with ambulatory BP, overnight urinary melatonin excretion and actigraphy. With regard to adjusted mean comparisons using analysis of covariance, the light-at-night group (average: >= 5 lux; n = 109) showed significantly higher nighttime systolic BP (SBP; adjusted mean: 120.8 vs. 116.5 mmHg, p = 0.01) and diastolic BP (70.1 vs. 67.1 mmHg, p < 0.01) compared with the Darker group (average: 55 lux; n = 419) independently of potential confounding factors including overnight urinary melatonin excretion and actigraphic sleep quality. We observed consistent associations between light-at-night and nighttime BP in different cutoff values for light-at-night intensity (i.e. 3 and 10 lux). In conclusion, exposure to light-at-night in home settings is significantly associated with increased nighttime BP in elderly individuals independently of overnight urinary melatonin excretion. A 4.3 mmHg increase in nighttime SBP is associated with a 6.1% increase in total mortality, which corresponds to approximately 10 000 annual excess deaths in Japanese elderly population.
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