期刊
JOURNAL OF INFECTIOUS DISEASES
卷 213, 期 6, 页码 985-991出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv525
关键词
Epstein-Barr virus; P. falciparum malaria; Burkitt lymphoma; chronic infection; infection dynamics; co-infection
资金
- National Institutes of Health [R01 CA102667, R01 CA134051]
- National Health and Medical Research Council, Australia [APP1080001]
Endemic Burkitt lymphoma is associated with Epstein-Barr virus (EBV) and Plasmodium falciparum coinfection, although how P. falciparum exposure affects the dynamics of EBV infection is unclear. We have used a modeling approach to study EBV infection kinetics in a longitudinal cohort of children living in regions of high and low malaria transmission in Kenya. Residence in an area of high malaria transmission was associated with a higher rate of EBV expansion during primary EBV infection in infants and during subsequent episodes of EBV DNA detection, as well as with longer episodes of EBV DNA detection and shorter intervals between subsequent episodes of EBV DNA detection. In addition, we found that concurrent P. falciparum parasitemia also increases the likelihood of the first and subsequent peaks of EBV in peripheral blood. This suggests that P. falciparum infection is associated with increased EBV growth and contributes to endemic Burkitt lymphoma pathogenesis.
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