4.3 Article

Melatonin binding sites in senegal sole: Day/night changes in density and location in different regions of the brain

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CHRONOBIOLOGY INTERNATIONAL
卷 25, 期 4, 页码 645-652

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TAYLOR & FRANCIS INC
DOI: 10.1080/07420520802254437

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fish; melatonin binding sites; plasma melatonin; Solea senegalensis; diurnal variation

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We localized melatonin binding sites in different brain regions (optic tectum, telencephalon, cerebellum, hypothalamus, olfactory bulbs, and medulla oblongata) of Senegal sole, a species of aquaculture interest, and checked day/night changes in density (Bmax) at mid-light (ZT06) and mid-dark (ZT18). Plasma melatonin was measured using a radioimmunoassay, while binding assays were performed using 2-[125I]iodomelatonin as a radioligand. Plasma melatonin concentrations were significantly lower at mid-light (189.546pg/ml) than mid-dark (455.5163 pg/ml). Values of Bmax were statistically significantly higher in the optic tectum (5.60.6 and 12.31fmol/mg prot, at mid-light and mid-dark, respectively) and in the cerebellum (7.71.1 and 10.61.3 fmol/mg prot, at mid-light and mid-dark, respectively). Significant day/night differences were only observed in these two tissues. These results show for the first time the distribution of melatonin binding sites within the brain of a flatfish species and their lack of down-regulation.

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