期刊
CHROMOSOME RESEARCH
卷 21, 期 6-7, 页码 615-625出版社
SPRINGER
DOI: 10.1007/s10577-013-9385-5
关键词
Noncoding RNA; Long noncoding RNA; Chromatin; Histone modifications; DNA methylation; Genomic imprinting; X chromosome inactivation; Kcnq1ot1; Xist; Replication; PRC1; PRC2
资金
- Swedish Cancer Research foundation [100422]
- Swedish Research Council [VR-M:K2011-66X-20781-04-3, VR-NT: 621-2011-4996]
- Barncancerfonden [PROJ11/067]
Along the lines of established players like chromatin modifiers and transcription factors, noncoding RNA (ncRNA) are now widely accepted as one of the key regulatory molecules in epigenetic regulation of transcription. With increasing evidence of ncRNAs in the establishment of gene silencing through their ability to interact with major chromatin modifiers, in the current review, we discuss their prospective role in the area of inheritance and maintenance of these established silenced states which can be reversible or irreversible in nature. In addition, we attempt to understand and speculate how these RNA dependent or independent maintenance mechanisms differ between each other in a developmental stage, tissue, and gene-specific manner in different biological contexts by utilizing known/unknown regulatory factors.
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