期刊
CHROMOSOME RESEARCH
卷 21, 期 1, 页码 27-36出版社
SPRINGER
DOI: 10.1007/s10577-012-9335-7
关键词
Centromeres; Chromosomes; Chromatin; Centromere protein A; Epigenetics
资金
- CIHR [MOP-106548]
- CCSRI [700824]
The Centromere is a unique chromosomal locus where the kinetochore is formed to mediate faithful chromosome partitioning, thus maintaining ploidy during cell division. Centromere identity is inherited via an epigenetic mechanism involving a histone H3 variant, called centromere protein A (CENP-A) which replaces H3 in centromeric chromatin. In spite of extensive efforts in field of centromere biology during the past decade, controversy persists over the structural nature of the CENP-A-containing epigenetic mark, both at nucleosomal and chromatin levels. Here, we review recent findings and hypotheses regarding the structure of CENP-A-containing complexes.
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