期刊
CHROMOSOME RESEARCH
卷 20, 期 5, 页码 635-656出版社
SPRINGER
DOI: 10.1007/s10577-012-9290-3
关键词
CenH3/CENP-A; Centromere; Kinetochore; Epigenetics; Heterochromatin; Histone modification; Neurospora crassa; Fusarium graminearum
资金
- American Cancer Society [RSG-08-030-01-CCG]
- NIH [R01GM097637]
How centromeres are assembled and maintained remains one of the fundamental questions in cell biology. Over the past 20 years, the idea of centromeres as precise genetic loci has been replaced by the realization that it is predominantly the protein complement that defines centromere localization and function. Thus, placement and maintenance of centromeres are excellent examples of epigenetic phenomena in the strict sense. In contrast, the highly derived point centromeres of the budding yeast Saccharomyces cerevisiae and its close relatives are counterexamples for this general principle of centromere maintenance. While we have learned much in the past decade, it remains unclear if mechanisms for epigenetic centromere placement and maintenance are shared among various groups of organisms. For that reason, it seems prudent to examine species from many different phylogenetic groups with the aim to extract comparative information that will yield a more complete picture of cell division in all eukaryotes. This review addresses what has been learned by studying the centromeres of filamentous fungi, a large, heterogeneous group of organisms that includes important plant, animal and human pathogens, saprobes, and symbionts that fulfill essential roles in the biosphere, as well as a growing number of taxa that have become indispensable for industrial use.
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