期刊
CHROMOSOME RESEARCH
卷 18, 期 1, 页码 137-145出版社
SPRINGER
DOI: 10.1007/s10577-009-9105-3
关键词
DNA replication origin; Chromatin; Nucleosome; DNA Loops; Transcription; Mitosis; Reprogramming
资金
- FRM
- ARC
- European Research Council
- ANR
- Association pour la Recherche contre le Cancer
- Ligue Nationale contre le Cancer
During each cell cycle, thousands of DNA replication origins are activated in each cell of a metazoan organism. Although they appear site-specific, their usage and organization are rather plastic. Moreover, no strict sequence specificity has been observed in contrast to bacterial or Saccharomyces cerevisiae DNA replication origins. Epigenetic regulation linked to chromatin structure, chromosome organization, and transcription has been suggested to explain how DNA replication origins are selected and recognized by replication initiation factors. In this paper, we review these epigenetic features and discuss how, during the previous mitosis, chromosomal architecture might prepare DNA replication origins for a new cell cycle.
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