期刊
CHROMOSOME RESEARCH
卷 17, 期 5, 页码 621-635出版社
SPRINGER
DOI: 10.1007/s10577-009-9061-y
关键词
Caenorhabditis elegans; dosage compensation complex gene expression; condensin
资金
- National Institute of Health Grant [R01 GM079533]
- Predoctoral Training Grant in Genetics [NIH T32 GM07544]
Dosage compensation in the nematode Caenorhabditis elegans is achieved by the binding of a condensin-like dosage compensation complex (DCC) to both X chromosomes in hermaphrodites to downregulate gene expression two-fold. Condensin IDC, a sub-part of the DCC, differs from the mitotic condensin I complex by a single subunit, strengthening the connection between dosage compensation and mitotic chromosome condensation. The DCC is targeted to X chromosomes by initial binding to a number of recruiting elements, followed by dispersal or spreading to secondary sites. While the complex is greatly enriched on the X chromosomes, many sites on autosomes also bind the complex. DCC binding does not correlate with DCC-mediated repression, suggesting that the complex acts in a chromosome-wide manner, rather than on a gene-by-gene basis. Worm dosage compensation represents an excellent model system to study how condensin-mediated changes in higher order chromatin organization affect gene expression.
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