期刊
CHROMOSOME RESEARCH
卷 18, 期 1, 页码 103-113出版社
SPRINGER
DOI: 10.1007/s10577-009-9086-2
关键词
DNA replication; S phase program; cyclin; cyclin dependent kinase (CDK); checkpoint protein 1 (Chk1)
DNA replication is key to ensuring the complete duplication of genomic DNA prior to mitosis and is tightly regulated by both cell cycle machinery and checkpoint signals. Regulation of the S phase program occurs at several stages, affecting origin firing, replication fork elongation, fork velocity, and fork stability, all of which are dependent on S-phase-promoting kinase activity. Somatic mammalian cells use well-established origin programs by which specific regions of the genome are replicated at precise times. However, the mechanisms by which S phase kinases regulate origin firing in mammals are largely unknown. Here, we discuss recent advances in the understanding of how S phase programs are regulated in mammals at the correct regions and at the appropriate times.
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