期刊
CHROMOSOME RESEARCH
卷 18, 期 1, 页码 115-125出版社
SPRINGER
DOI: 10.1007/s10577-009-9091-5
关键词
time of replication; genomics; transcription; epigenetic; genomic stability; Microarrays
资金
- Israel Science Foundation
- Israel Cancer Research Foundation
- Israel Cancer Association
- European Commission [503576]
- Weinkselbaum Family Medical Research Fund
- Agilent Foundation Research Technology
Microarray technology has facilitated the research of eukaryotic DNA replication on a genome-wide scale. Recent studies have shed light on the association between time of replication and chromosome structure, on the organization principles of the replication program, and on the correlation between replication timing and transcription. In this review, we summarize various genomic measurement approaches and the biological insights achieved through applying them in the study of the mammalian replication program.
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