期刊
CHROMOSOME RESEARCH
卷 17, 期 5, 页码 659-669出版社
SPRINGER
DOI: 10.1007/s10577-009-9057-7
关键词
X inactivation; dosage compensation; Eutheria; marsupial; evolution
资金
- CNRS
- EU
- Fondation pour la Recherche Mediacale
- ANR
In most mammals, X-chromosome inactivation is used as the strategy to achieve dosage compensation between XX females and XY males. This process is developmentally regulated, resulting in the differential treatment of the two X chromosomes in the same nucleus and mitotic heritability of the silent state. A lack of dosage compensation in an XX embryo is believed to result in early lethality, at least in eutherians. Given its fundamental importance, X-chromosome inactivation would be predicted to be a highly conserved process in mammals. However, recent studies have revealed major mechanistic differences in X inactivation between eutherians and marsupials, suggesting that the evolution of the X chromosome as well as developmental differences between mammals have led to diverse evolutionary strategies for dosage compensation.
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