期刊
JOURNAL OF INFECTIOUS DISEASES
卷 213, 期 4, 页码 649-658出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv440
关键词
Klebsiella pneumoniae; pneumonia; capsule; fimK; EAL domain; murine model
资金
- Novartis Vaccines and Diagnostics (Pediatric Infectious Diseases Fellowship Award)
- National Institutes of Health [R01-DK080752, P50-DK064540, T32-AI106688, R01AI104732]
- Child Health Research Center at Washington University School of Medicine [K12-HD076224]
Klebsiella pneumoniae, a chief cause of nosocomial pneumonia, is a versatile and commonly multidrug-resistant human pathogen for which further insight into pathogenesis is needed. We show that the pilus regulatory gene fimK promotes the virulence of K. pneumoniae strain TOP52 in murine pneumonia. This contrasts with the attenuating effect of fimK on urinary tract virulence, illustrating that a single factor may exert opposing effects on pathogenesis in distinct host niches. Loss of fimK in TOP52 pneumonia was associated with diminished lung bacterial burden, limited innate responses within the lung, and improved host survival. FimK expression was shown to promote serum resistance, capsule production, and protection from phagocytosis by host immune cells. Finally, while the widely used K. pneumoniae model strain 43816 produces rapid dissemination and death in mice, TOP52 caused largely localized pneumonia with limited lethality, thereby providing an alternative tool for studying K. pneumoniae pathogenesis and control within the lung.
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