期刊
CHROMOSOMA
卷 117, 期 6, 页码 521-533出版社
SPRINGER
DOI: 10.1007/s00412-008-0173-5
关键词
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资金
- Cancer Research UK
- Wellcome Trust
- Human Frontier Science Program
- Lister Research Institute Prize
- Association for International Cancer Research
- Medical Research Council
- MRC [G0701147] Funding Source: UKRI
- Medical Research Council [G0701147] Funding Source: researchfish
To maintain their genetic integrity, eukaryotic cells must segregate their chromosomes properly to opposite poles during mitosis. This process mainly depends on the forces generated by microtubules that attach to kinetochores. During prometaphase, kinetochores initially interact with a single microtubule that extends from a spindle pole and then move towards a spindle pole. Subsequently, microtubules that extend from the other spindle pole also interact with kinetochores and, eventually, each sister kinetochore attaches to microtubules that extend from opposite poles (sister kinetochore bi-orientation). If sister kinetochores interact with microtubules in wrong orientation, this must be corrected before the onset of anaphase. Here, I discuss the processes leading to bi-orientation and the mechanisms ensuring this pivotal state that is required for proper chromosome segregation.
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