Separation Performance of MOFs Zn(ISN)2•2H2O as Stationary Phase for High-Resolution GC

Metal-organic frameworks (MOFs) as a new type of porous materials have attracted tremendous attention for their potential applications in recent years. Here, we used a simple chiral MOF, Zn(ISN)(2)center dot 2H(2)O, as chiral stationary phase for high-resolution gas chromatography. A Zn(ISN)(2)center dot 2H(2)O-coated fused-silica capillary column (3 m long x 75 mu m i.d.) was fabricated by using a dynamic coating method with ethanol suspension of Zn(ISN)(2)center dot 2H(2)O (1 mg mL(-1)). Then, the coating properties, polarity, and column efficiency of the column were studied. The column efficiency of Zn(ISN)(2)center dot 2H(2)O-coated column was up to 3,020 plates m(-1). The separation performance was investigated by separating a wide range of organic compounds such as Grob test mixtures, alkanes, alcohols, isomers, and racemates. The relative standard deviations for the five replicate separations of alanine were 0.32 and 2.6 % for retention time and peak area, respectively. The experimental results showed that the new stationary phase possesses high column efficiency, good reproducibility, excellent selectivity, and chiral recognition ability.