MSPD-GC-MS-MS Determination of Residues of 15 Organic Nitrogen-Containing Pesticides in Vegetables

A novel and simple method for determination of 15 organic nitrogen-containing pesticides in vegetables using matrix solid-phase dispersion (MSPD) coupled with gas chromatography tandem mass spectrometry (GC-MS-MS) has been developed. The efficiencies of different sorbents (florisil, silicone, neutral alumina) for the MSPD were compared. Mean recoveries of the method using neutral alumina varied from 73.26 to 111.83% with relative standard deviations of 0.79-15.33% in the concentration range of 0.01, 0.02 and 0.05 mg kg(-1). The limits of detection were typically in the 0.0007-0.0320 mg kg(-1) range, which were 10-100 times lower than the maximum residue levels established by the European Union. This method was applied to residue detection in vegetables, in which organic nitrogen-containing compounds were detected at low concentrations.