期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 34, 页码 9876-9880出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201503936
关键词
cross-coupling; ethers; nickel; radicals; synthetic methods
资金
- NIGMS [R01 GM100985]
A new substrate class for nickel-catalyzed C(sp(3)) cross-coupling reactions is reported. alpha-Oxy radicals generated from benzylic acetals, TMSCl, and a mild reductant can participate in chemoselective cross-coupling with aryl iodides using a 2,6-bis(N-pyrazolyl)pyridine (bpp)/Ni catalyst. The mild, base-free conditions are tolerant of a variety of functional groups on both partners, thus representing an attractive C-C bond-forming approach to dialkyl ether synthesis. Characterization of a [(bpp)NiCl] complex relevant to the proposed catalytic cycle is also described.
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