期刊
JOURNAL OF INFECTIOUS DISEASES
卷 212, 期 12, 页码 1862-1868出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv278
关键词
ciprofloxacin-resistant E. coli; extra-intestinal pathogenic E. coli; E. coli ST131-H30; E. coli ST405; urinary tract infections
资金
- Children's Discovery Institute of Washington University
- St. Louis Children's Hospital
- Doris Duke Clinical Research Foundation
- National Institutes of Health [5P30 DK052574]
- Office of Research and Development, Medical Research Service, Department of Veterans Affairs [1 I01 CX000920-01A1]
- Medical Faculty of Munster [BD9817044]
Background. The reservoir of pathogenic ciprofloxacin-resistant Escherichia coli remains unknown. Methods. We conducted a prospective cohort study of 80 healthy twins and their mothers to determine the frequency of excretion of ciprofloxacin-resistant, potentially pathogenic E. coli. Stool specimens were cultured selectively for ciprofloxacin-resistant gram-negative bacteria. Isolates were categorized on the basis of additional resistance and virulence profiles. We also prospectively collected clinical metadata. Results. Fifteen children (19%) and 8 mothers (20%) excreted ciprofloxacin-resistant E. coli at least once. Overall, 33% of 40 families had at least 1 member whose stool specimen yielded ciprofloxacin-resistant E. coli on culture. Fifty-seven submitted stool specimens (2.8%) contained such organisms; clones ST131-H30 and ST405 accounted for 52 and 5 of the positive specimens, respectively. Length of hospital stay after birth (P = .002) and maternal colonization (P = .0001) were associated with subsequent childhood carriage of ciprofloxacin-resistant E. coli; antibiotic use, acid suppression, sex, mode of delivery, and maternal perinatal antibiotic use were not. Ciprofloxacin-resistant E. coli were usually resistant to additional antibiotic classes, and all had virulence genotypes typical of extraintestinal pathogenic E. coli. Conclusions. Healthy children and their mothers commonly harbor ciprofloxacin-resistant E. coli with pathogenic potential.
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