期刊
CHROMATOGRAPHIA
卷 70, 期 5-6, 页码 691-698出版社
SPRINGER HEIDELBERG
DOI: 10.1365/s10337-009-1226-5
关键词
Column liquid chromatography; Molecularly imprinted polymers; Chiral separation; Low-density monolithic column; (S)-Naproxen
资金
- National Natural Science Foundation of China [20575045]
- Natural Science Foundation of Tianjin [08JCYBJC02000]
This work is a first effort to prepare a low-density imprinted monolithic column for LC. The new molecularly imprinted polymer monolith was prepared with 30% (w/w) monomers in the pre-polymerization mixture while general high-density monoliths are prepared with 40% monomers. The resulting low-density (S)-naproxen-imprinted monolith produced better chiral resolution of rac-naproxen (R (s) = 1.55) and column efficiencies of imprinted molecules up to 2,860 plates m(-1). Morphological characteristics of low density imprinted monolith was further studied by mercury intrusion porosimetry, scanning electron microscopy (SEM) and nitrogen sorption method. The experiments demonstrated that the strategy of low-density column may be one of a potential approach to the improvement of column efficiency of an imprinted stationary phase.
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