期刊
JOURNAL OF INFECTIOUS DISEASES
卷 213, 期 10, 页码 1596-1605出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv761
关键词
Streptococcus pneumoniae; Haemophilus influenzae; Staphylococcus aureus; pneumococcal conjugate vaccine; serotype replacement
资金
- Wyeth/Pfizer [0887X-101801]
- National Institute of Allergy and Infectious Diseases [R56AI110449]
- National Institute on Aging, National Institutes of Health [P30AG021342]
- Yale Center for Clinical Investigation [ULI TR000142]
- Bill and Melinda Gates Foundation [OPP1114733]
- Yale School of Medicine
- Bill and Melinda Gates Foundation [OPP1114733] Funding Source: Bill and Melinda Gates Foundation
Background. Cocolonization by Streptococcus pneumoniae and Haemophilus influenzae among children has been noted in numerous studies, as has an inverse relationship involving colonization with these species and Staphylococcus aureus. Interactions among these pathogens could mediate unanticipated outcomes of clinical interventions, including changes in H. influenzae and S. aureus disease incidence following pneumococcal vaccine introduction. However, it remains unclear whether cocolonization patterns represent true interspecies interactions or whether they result from confounding factors. Methods.aEuro integral We investigated polymicrobial carriage using longitudinal data from 369 Bedouin children and 400 Jewish children in Israel who were enrolled in a 7-valent pneumococcal conjugate vaccine (PCV7) trial. Children were swabbed 10 times between 2 and 30 months of age. Results.aEuro integral The pathogens followed distinct age and seasonal distributions, but polymicrobial carriage associations persisted after controlling for these and other confounding factors. Receipt of PCV7 resulted in pneumococcal serotype replacement but did not influence total carriage of S. pneumoniae, H. influenzae, or S. aureus. Conclusions.aEuro integral The fact that S. pneumoniae, H. influenzae, and S. aureus polymicrobial carriage patterns do not result from confounding by age and season supports the idea of active interspecies interactions. However, pneumococcal serotype replacement may prevent changes in H. influenzae and S. aureus carriage among PCV7 recipients.
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