4.7 Article

NETosis in Neonates: Evidence of a Reactive Oxygen Species-Independent Pathway in Response to Fungal Challenge

期刊

JOURNAL OF INFECTIOUS DISEASES
卷 213, 期 4, 页码 634-639

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv435

关键词

neonates; neutrophils; NETs; glucan; fungi

资金

  1. National Institutes of Health (NIH) [GM066194, P20GM103537, F31DE023726]
  2. United Negro College Fund/Merck Graduate Science Research Dissertation Fellowship

向作者/读者索取更多资源

Release of neutrophil extracellular traps (NETs) is a significant antimicrobial host defense mechanism in adults. In neonates, fungal sepsis is a frequent cause of morbidity and mortality and may be a consequence of inadequate neutrophil defense functions. Like neutrophils from adult donors, we found that neutrophils from neonates formed robust cellular aggregates and released NETs in response to fungal beta-glucan and Candida albicans hyphae when presented with extracellular matrix. Therefore, in response to fungal stimulation, neonatal neutrophils are capable of NETosis. Neonate susceptibility to fungal infections may not be due to an inability of their neutrophils to produce NETs.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据