期刊
JOURNAL OF INFECTIOUS DISEASES
卷 213, 期 4, 页码 634-639出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv435
关键词
neonates; neutrophils; NETs; glucan; fungi
资金
- National Institutes of Health (NIH) [GM066194, P20GM103537, F31DE023726]
- United Negro College Fund/Merck Graduate Science Research Dissertation Fellowship
Release of neutrophil extracellular traps (NETs) is a significant antimicrobial host defense mechanism in adults. In neonates, fungal sepsis is a frequent cause of morbidity and mortality and may be a consequence of inadequate neutrophil defense functions. Like neutrophils from adult donors, we found that neutrophils from neonates formed robust cellular aggregates and released NETs in response to fungal beta-glucan and Candida albicans hyphae when presented with extracellular matrix. Therefore, in response to fungal stimulation, neonatal neutrophils are capable of NETosis. Neonate susceptibility to fungal infections may not be due to an inability of their neutrophils to produce NETs.
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