期刊
JOURNAL OF INFECTION AND CHEMOTHERAPY
卷 21, 期 5-6, 页码 330-339出版社
ELSEVIER
DOI: 10.1016/j.jiac.2015.02.012
关键词
Bacteremia; Infective endocarditis; Methicillin-resistant Staphylococcus aureus; Coagulase-negative staphylococci; Enterococcus faecalis; Vancomycin-resistant enterococci
Gram-positive cocci are a well-recognised major cause of nosocomial infection worldwide. Bloodstream infections due to methicillin-resistant Staphylococcus aureus, methicillin-resistant coagulase-negative staphylococci, and multi-drug resistant enterococci are a cause of concern for physicians due to their related morbidity and mortality rates. Aim of this article is to review the current state of knowledge regarding the management of BSI caused by staphylococci and enterococci, including infective endocarditis, and to identify those factors that may help physicians to manage these infections appropriately. Moreover, we discuss the importance of an appropriate use of antimicrobial drugs, taking in consideration the in vitro activity, clinical efficacy data, pharmacokinetic/pharmacodynamic parameters, and potential side effects. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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