期刊
CHIRALITY
卷 26, 期 2, 页码 121-127出版社
WILEY
DOI: 10.1002/chir.22279
关键词
enantiomers; diterpene-derived thiourea; maleimide; Michael reaction; succinimide
资金
- National Natural Science Foundation of China [20772113]
- Doctoral Foundation of Xinxiang Medical University
A doubly stereocontrolled organocatalytic asymmetric Michael addition to the synthesis of substituted succinimides is described. Starting from aldehydes and maleimides, both enantiomers of the succinimides could be obtained in high to excellent yields (up to 98%) and enantioselectivities (up to 99%) when one of the two special chiral diterpene-derived bifunctional thioureas was individually used as a catalyst. Moreover, these catalysts can be efficiently used in large-scale catalytic synthesis with the same level of yield and enantioselectivity. Chirality 00:000-000, 2014. (c) 2014 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据