期刊
CHIRALITY
卷 25, 期 11, 页码 735-742出版社
WILEY-BLACKWELL
DOI: 10.1002/chir.22206
关键词
capillary electrophoresis; chiral separations; sulfated cyclofructan 6; sulfated cyclodextrins; basic pharmaceuticals
资金
- Science and Technology Department of Henan Province, China [092102310227]
- Education Department of Henan Province, China [2007150019, 2008A150012]
- Korea Research Foundation [2012R1A1A2005923]
- Kyungpook National University Research Fund
- National Research Foundation of Korea [2012R1A1A2005923] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Sulfated cyclofructan 6 (S-CF6) and sulfated cyclodextrins (S--, -, -CDs) are highly selective chiral selectors for the enantioseparation of basic solutes. In this study, S-CF6 was introduced for the enantiomeric separation of four basic pharmaceuticals (including tamsulosin, tiropramide, bupivacaine, and norephedrine) by capillary electrophoresis (CE), and the enantiomeric separation performance was compared with S--, -, -CDs. The effects of the chiral selector type, chiral selector concentration, operating voltage, and column temperature were examined and optimized. Excellent resolutions were obtained for all solutes on these chiral selectors. Chirality 25:735-742, 2013. (c) 2013 Wiley Periodicals, Inc.
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