期刊
CHIRALITY
卷 22, 期 1, 页码 63-68出版社
WILEY
DOI: 10.1002/chir.20707
关键词
alpha-hydroxyphosphonates; enantiodiscrimination; nuclear magnetic resonance spectroscopy; alpha-cyclodextrin
资金
- Polish Ministry of Science and Higher Education [PBZ-KBN-126/T09/2004]
- Foundation for Polish Science
alpha-Cyclodextrin was shown to be convenient chemical shift reagent for determination of the enantiomeric composition of alpha-hydroxyphosphonic acids by means of P-31 NMR. The developed methodology appeared to be reliable, repetitive, easy to perform and simple for interpretation. Enantiomeric discrimination in the P-31 NMR spectra for 12 of 13 studied hydroxyphosphonates was achieved, with baseline separation of resonances obtained for eight compounds. In those cases, the chemical nonequivalence values ranged from 0.069 to 0.313 ppm. The Studies showed that enantioselectivity is strongly influenced by the solution pD and the optimal condition was found at pD 2 or 10 depending on the guest structure. On the basis of the ROESY spectra the complexation modes of selected hydroxyphosphonates with alpha-cyclodextrin was postulated. Chirality 22:63-68, 2010. (C) 2009 Wiley-Liss. Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据