期刊
CHIRALITY
卷 21, 期 9, 页码 850-856出版社
WILEY
DOI: 10.1002/chir.20716
关键词
rearrangement; aminoalcohols; trifluoracetic anhydride
beta-Amino alcohols derived from natural amino acids have been used extensively as a powerful source of chirality. Transformation of the hydroxy group of these beta-amino alcohols into a good leaving group, by using trifluoroacetic anhydride, led to rearranged beta-amino alcohols in good yields and with high enantiomeric excesses. This rearrangement has allowed the transformation of substituted prolinols to substituted 3-hydroxypiperidines and linear beta-amino alcohols, issued from natural amino acids, to rearranged p-amino alcohols. Chirality 21:850-856, 2009. (C) 2009 Wiley-Liss, Inc.
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